Modulation of Immune Responses by Nutritional Ligands of Aryl Hydrocarbon Receptor

Accumulating evidence indicates that nutrition can modulate the immune system through metabolites, either produced by host digestion or microbiota metabolism. In this review, we focus on dietary metabolites are agonists of Aryl hydrocarbon Receptor (AhR). AhR is a ligand-activated transcription factor, initially characterized for its interaction with xenobiotic pollutants. Numerous studies have shown also recognizes indoles and tryptophan catabolites originating from compounds commensal bacteria. Here, review recent work employing diet manipulation to address impact nutritional responses, both locally in intestine at distant sites. particular, examine physiological role these cell development functions (including T lymphocytes, innate-like lymphoid cells, mononuclear phagocytes) their effect inflammatory disorders.